Formulation and Evaluation of Controlled-Release Dicyclomine Tablets Using Araucaria columnaris Gum as a Natural Polymer

Abstract

Aim: To formulate and evaluate the controlled-release Dicyclomine tablets using Araucaria columnaris gum as a natural polymer.

Methods: The gum was extracted, purified and evaluated for its physical & chemical properties, such as swelling capacity, viscosity and compatibility with the active pharmaceutical ingredient. Tablets were prepared with different concentrations of Araucaria columnaris gum (10-30% w/w) and assessed for pre-compression parameters including flowability as well as post-compression characteristics like hardness, friability, weight consistency and drug content uniformity.

Results: Dissolution studies were carried out in-vitro using a USP Type II apparatus, simulating gastric conditions (pH:1.2) for the first two hours, followed by a phosphate buffer solution (pH:6.8) for the subsequent 10 hours. Drug release data were fitted into various kinetic models to evaluate the release mechanism, with the optimal formulation demonstrating extended release over 12 hours through a combination of diffusion and polymer matrix erosion.

Conclusion: This study highlights the suitability of Araucaria columnaris gum as an effective matrix-forming agent for controlled-release tablets, reducing the need for multiple daily doses and improving treatment outcomes for dicyclomine hydrochloride.