Formulation and Characterization of Copper Oxide Solid Lipid Micro-Particles
Keywords:
Copper Oxide, Scanning Electron Microscopy, Solid Lipid Micro-Particles, Zeta PotentialAbstract
Aim: The main aim of this study is to evaluate the morphology, particle size, zeta potential and anti-microbial activity of the formulated micro-particles to establish their potential application.
Methods: CuO-SLMs were synthesized using the micro-emulsion-based method by incorporating stearylamine and Tween 80. Characterization was done by SEM analysis and antimicrobial activity was evaluated using pour plate and streaking methods.
Results: SEM confirmed spherical micro-particles with smooth surfaces and a size range of 2 µm, showing good water dispersibility. The CuO-SLMs demonstrated superior antimicrobial activity against both Gram-positive and Gram-negative bacteria compared to standard antibiotic Ciprofloxacin.
Conclusion: This study effectively formulated CuO-MPs utilising the micro-emulsion-based approach. The synthesised micro-particles demonstrated superior spherical shape, a smooth surface and a restricted size distribution within the micrometre scale. The zeta potential study verified the colloidal stability of the formulation, demonstrating little aggregation and effective dispersion in aqueous conditions. Moreover, the CuO-SLMs exhibited substantial antibacterial efficacy against the evaluated bacterial strains, surpassing the conventional antibiotic Ciprofloxacin.
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